Protein Intake Is Critical At every dose level, prioritize protein consumption
If using oral contraceptives, you'll need a backup method or non-oral contraception for 4 weeks after starting Zepbound and for 4 weeks after each dose increase due to reduced pill effectiveness
Small, frequent sips are often better tolerated than drinking large amounts at once
A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
These medications can be highly effective for weight loss and blood sugar management, but because they slow digestion and gastric emptying, some patients may experience fewer bowel movements, harder stools, or discomfort
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